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We have a general interest in development and application of innovative technologies for characterising different molecular layers, including (epi)genome and transcriptome, at the single-cell resolution. We further decipher the connectivity and interplay between those molecular layers within a single cell and their impact on cellular identity and function. We constantly explore new avenues towards translating our research into the clinic.

 

The lab is specifically focused on studying (epi)genome  (in)stability in early human development with application to the clinic, e.g. preimplantation genetic testing (PGT) and non-invasive prenatal testing (NIPT). Our research lies at the intersection of classical genetics, molecular and developmental genetics, clinical genetics, bioinformatics and artificial intelligence. 

 

Team

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Masoud Zamani Esteki
Principal investigator
 
See Masoud's vision here
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Anouk Janssen
 PhD candidate

Liquid biopsy
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Rebekka Koeck
PhD candidate
Cellular omics
question-mark-human-head-symbol-thinking
You
Postdoc scientist
Medical machine learning
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Jeroen Meekels 
Senior research technician

Single-cell genomics
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Maryn Reyneke
PhD candidate

Ethics of innovations in Reproductive Medicine
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Rick Essers
PhD candidate
Genomic organization
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Darina Obuhova
PhD candidate

Lineage branching
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Naomi Roberts
Internship student​

Clinical epigenomics
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Nikki in ‘t Groen
Internship student​

Clinical epigenomics
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Wanwisa van Dijk
Project manager & senior technician


 

Alumni

  • Emma Zwilling (postgraduate student)

  • Sanne Romans (undergraduate student)

  • Nina Rodenburg (undergraduate student)

  • Lisa Sackman (undergraduate student)

  • Shanna Overeem (undergraduate student)

  • Gaby Schobers (postgraduate student)

  • Britt Thomassen (undergraduate student)

  • Jesko Wagner (undergraduate student)

Contact

Email: masoud.zamaniesteki@mumc.nl
Tel:  +31 43 38 75306
Address:
Laboratory of Cellular Genomic Medicine
Department of Clinical Genetics
Maastricht UMC+

P. Debyelaan 25

6229 HX Maastricht

The Netherlands

 

Fertilization

Chromosome instability (CIN)