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We have a general interest in development and application of innovative technologies for characterising different molecular layers, including (epi)genome and transcriptome, at the single-cell resolution. We further decipher the connectivity and interplay between those molecular layers within a single cell and their impact on cellular identity and function. We constantly explore new avenues towards translating our research into the clinic.
The lab is specifically focused on studying (epi)genome (in)stability in early human development with application to the clinic, e.g. preimplantation genetic testing (PGT) and non-invasive prenatal testing (NIPT). Our research lies at the intersection of classical genetics, molecular and developmental genetics, clinical genetics, bioinformatics and artificial intelligence.
Fertilization
Chromosome instability (CIN)
Team
Your name
Postdoc scientist
Medical machine learning
Rebekka Koeck
PhD candidate
Cellular omics
Lisa Sackmann
Internship student
Embryonic mosaicism
Jeroen Meekels
Senior research technician
Single-cell genomics
Nina Rodenburg
Internship student
Non-invasive genetic testing
Rick Essers
PhD candidate
Genomic organization
Shanna Overeem
Internship student
Clinical Epigenomics
Dominique Pellaers
PhD candidate
Liquid biopsy
Alumni
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Gaby Schobers (postgraduate student)
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Britt Thomassen (undergraduate student)
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Jesko Wagner (undergraduate student)
Contact
Email:
Tel: +31 43 38 75306
Address:
Laboratory of Cellular Genomic Medicine
Department of Clinical Genetics
Maastricht UMC+
P. Debyelaan 25
6229 HX Maastricht
The Netherlands