see the simplified story here


We have a general interest in development and application of innovative technologies for characterising different molecular layers, including (epi)genome and transcriptome, at the single-cell resolution. We further decipher the connectivity and interplay between those molecular layers within a single cell and their impact on cellular identity and function. We constantly explore new avenues towards translating our research into the clinic.


The lab is specifically focused on studying (epi)genome  (in)stability in early human development with application to the clinic, e.g. preimplantation genetic testing (PGT) and non-invasive prenatal testing (NIPT). Our research lies at the intersection of classical genetics, molecular and developmental genetics, clinical genetics, bioinformatics and artificial intelligence. 


Chromosome instability (CIN)



Masoud Zamani Esteki
Principal investigator
See Masoud's vision here
Anouk Janssen
 PhD candidate

Liquid biopsy
Rebekka Koeck
PhD candidate
Cellular omics
Postdoc scientist
Medical machine learning
Jeroen Meekels 
Senior research technician

Single-cell genomics
Maryn Reyneke
PhD candidate

Ethics of innovations in Reproductive Medicine


  • Emma Zwilling (postgraduate student)

  • Sanne Romans (undergraduate student)

  • Nina Rodenburg (undergraduate student)

  • Lisa Sackman (undergraduate student)

  • Shanna Overeem (undergraduate student)

  • Gaby Schobers (postgraduate student)

  • Britt Thomassen (undergraduate student)

  • Jesko Wagner (undergraduate student)

Rick Essers
PhD candidate
Genomic organization
Darina Obuhova
PhD candidate

Lineage branching
Naomi Roberts
Internship student​

Clinical epigenomics
Nikki in ‘t Groen
Internship student​

Clinical epigenomics


Tel:  +31 43 38 75306
Cellular Genomic Medicine
Department of Clinical Genetics
Maastricht UMC+

P. Debyelaan 25

6229 HX Maastricht

The Netherlands