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We have a general interest in development and application of innovative technologies for characterising different molecular layers, including (epi)genome and transcriptome, at the single-cell resolution. We further decipher the connectivity and interplay between those molecular layers within a single cell and their impact on cellular identity and function. We constantly explore new avenues towards translating our research into the clinic.
The lab is specifically focused on studying (epi)genome (in)stability in early human development with application to the clinic, e.g. preimplantation genetic testing (PGT) and non-invasive prenatal testing (NIPT). Our research lies at the intersection of classical genetics, molecular and developmental genetics, clinical genetics, bioinformatics and artificial intelligence.
Fertilization
Chromosome instability (CIN)
Team
Lisa Sackmann
Internship student​
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Embryonic mosaicism
Jeroen Meekels
Senior research technician
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Single-cell genomics
Nina Rodenburg
Internship student​
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Non-invasive genetic testing
Rick Essers
PhD candidate
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Genomic organization
Shanna Overeem
Internship student​
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Clinical Epigenomics​
Dominique Pellaers
PhD candidate
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Liquid biopsy
Alumni
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Gaby Schobers (postgraduate student)
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Britt Thomassen (undergraduate student)
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Jesko Wagner (undergraduate student)
Contact
Email:
Tel: +31 43 38 75306
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Address:
Cellular Genomic Medicine
Department of Clinical Genetics
Maastricht UMC+
P. Debyelaan 25
6229 HX Maastricht
The Netherlands