see the simplified story here

 

We have a general interest in development and application of innovative technologies for characterising different molecular layers, including (epi)genome and transcriptome, at the single-cell resolution. We further decipher the connectivity and interplay between those molecular layers within a single cell and their impact on cellular identity and function. We constantly explore new avenues towards translating our research into the clinic.

 

The lab is specifically focused on studying (epi)genome  (in)stability in early human development with application to the clinic, e.g. preimplantation genetic testing (PGT) and non-invasive prenatal testing (NIPT). Our research lies at the intersection of classical genetics, molecular and developmental genetics, clinical genetics, bioinformatics and artificial intelligence. 

Fertilization

Chromosome instability (CIN)

 

Team

Masoud Zamani Esteki
Principal investigator
 
See Masoud's vision here
question-mark-human-head-symbol-thinking
You
Postdoc scientist
Medical machine learning
Rebekka2.jpg
Rebekka Koeck
PhD candidate
Cellular omics
Jeroen Meekels 
Senior research technician
Single-cell genomics
Sanne Romans
Internship student​
Long-read sequencing
You
 PhD candidate
Lineage tracing
Rick Essers
PhD candidate
Genomic organization
You
 PhD candidate
Liquid biopsy
Emma Zwiling
Internship student
Embryo mosaicism

Alumni

  • Nina Rodenburg (undergraduate student)

  • Lisa Sackman (undergraduate student)

  • Shanna Overeem (undergraduate student)

  • Gaby Schobers (postgraduate student)

  • Britt Thomassen (undergraduate student)

  • Jesko Wagner (undergraduate student)

Contact

Email: masoud.zamaniesteki@mumc.nl
Tel:  +31 43 38 75306
Address:
Cellular Genomic Medicine
Department of Clinical Genetics
Maastricht UMC+

P. Debyelaan 25

6229 HX Maastricht

The Netherlands