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Darina Obukhova

PhD candidate

+31 43 38 71272

ORCiD

Laboratory of Cellular Genomic Medicine
Department of Clinical Genetics
Maastricht UMC+
P. Debyelaan 25
6229 HX Maastricht
The Netherlands

About me

I got my BS in Biological Sciences from University of Tsukuba in Japan, where I did a graduation project on the role of ubiquitin-proteasome protein degradation system in mice male infertility phenotype in the lab of UPS regulation, headed by Tomoki Chiba. Specifically, I analyzed double knockout mice models lacking genes for two proteasome-associated proteins, Ecm29 and PA200 using predominantly wet-lab methods. During that project, I realized that I would like interpret data more thoroughly using bioinformatic tools and expand my set of skills. Thus, I decided to do my master’s thesis in a bioinformatics lab, Functional Analysis in silico in the University of Tokyo, led by Kenta Nakai. There I investigated the specificity of E3 ubiquitin ligases gene expression and their role in human embryonic stem cell phenotype, analyzing their network and trying to understand the regulatory programs at the mRNA level.

I joined the Cellular Genomic Medicine group in September 2021 as a PhD candidate. During my PhD research, I will investigate the link between the incidence and nature of chromosomal aberrations pre- and post-zygotically and lineage specification, spanning a period from oocyte maturation to preimplantation embryo development.

 

Timeline

2021-

2018-2021

2012-2018

PhD student, “Cellular commitment during early embryogenesis and lineage branching”

Master of Science in Computational Biology and Medical Sciences, University of Tokyo, Japan

Bachelor of Science in Molecular Biology, University of Tsukuba, Japan

Personal touch

In my free time away from the research, I enjoy reading, wandering through nature, playing chess and snowboarding when there are mountains around.


 

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