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Alvin Meltsov

PhD candidate

+31 43 38 71272

ORCiD

Laboratory of Cellular Genomic Medicine
Department of Clinical Genetics
Maastricht UMC+
P. Debyelaan 25
6229 HX Maastricht
The Netherlands

About me

The nature of complex systems has always interested me. This interest guided me to study Biology at the University of Tartu. During my undergrad studies, I focused on cell biology and worked in a lab designing vectors to introduce point mutations to yeast helicase HMI1. After working in the laboratory for a year, I started to get into programming and statistics. Fascinated by the power of computational tools in biology and the emerging field of artificial intelligence, I decided to pivot towards bioinformatics.

As a bioinformatics analyst, I continued working on my interests at the Competence Centre on Health Technologies (CCHT), learning to use HPC environments for developing research and diagnostic pipelines. For my Bachelor's thesis, I explored non-invasive prenatal testing algorithms to find important genomic regions that could be targeted with a custom sequencing array. After finishing my thesis, I experimented with calculating polygenic risk scores from low coverage sequencing data accurately.

My studies continued at the Master's course of Computer Science at Tartu University, specialising in Data Science. I started working on transcriptional profiling methods and applying differential analysis (DE) on endometrial tissues from in vitro fertilisation (IVF) patients. Finally, I defended my Master's thesis on designing a non-iterative distance-based model for determining endometrial receptivity from a custom gene assay.

During my PhD, I plan to continue researching new models and tools for detecting pathologies or aberrations in the endometrium, hopefully contributing to increasing IVF success rate.



 

Timeline

2022-

2019-2021

2018 -

2017-2019

2015-2019

PhD student, “Single-cell transcriptomic landscape of human endometrium”

University of Tartu - M.S. Computer Science, Data Science curriculum

Competence Centre on Health Technologies

Student representative at Tartu University

University of Tartu - B.S. Biology and CS Minor
 

Personal touch

In my free time, I often find myself tuning my Vim or JetBrains configuration in Nix, listening to weird music, reading sci-fi or playing the guitar. I also enjoy experimenting with different ways to make input devices such as keyboards and mice more portable and ergonomic. Given tools and materials, I also like woodwork, especially restoring old furniture.

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